Humans have been ingesting lactic acid bacteria for thousands of years. The fact that select strains can survive passage through the gastrointestinal (GI) tract, along with recent advances in high-throughput genome engineering, makes many strains suitable as mother-ships to transport and deliver molecules in the GI tract.
Current projects in our laboratory related to the development of tailored probiotics are focussed on the delivery of anti-microbial molecules to eradicate select microbes from a complex microbial community. In addition, we are engineering probiotics to deliver immune-modulatory molecules to positively impact the immune-system. The efficacy of our therapeutic delivery systems are tested in various animal models of disease with collaborators both on- and off-campus.