University of Wisconsin–Madison

Tailored Probiotics

Humans have been ingesting lactic acid bacteria for thousands of years. The fact that select strains can survive passage through the gastrointestinal (GI) tract, along with recent advances in high-throughput genome engineering, makes many strains suitable as mother-ships to transport and deliver molecules in the GI tract.

Current projects in our laboratory related to the development of tailored probiotics are focussed on the delivery of anti-microbial molecules to eradicate select microbes from a complex microbial community. In addition, we are engineering probiotics to deliver immune-modulatory molecules to positively impact the immune-system. The efficacy of our therapeutic delivery systems are tested in various animal models of disease with collaborators both on- and off-campus.